Phenylbutazone, commonly known as Bute, is a non-steroidal anti-inflammatory drug that is used for musculo-skeletal analgesia (pain relief) and also has anti-pyretic (fever reduction) properties. It can be used for a wide range of problems such as muscle soreness and trauma, tendon and ligament sprain/strains, joint pain and arthritis. It also may be used to reduce pain and inflammation during an active infection and after surgery.
Dosage and Administration:
Please consult your veterinarian for dosage instructions, but in general it is recommended to not exceed 2 grams for a 1000 lb horse in a 24 hour period. A common dose is 1 gram bute, twice daily for a 1000 horse horse.
Side effects: It is not recommended for long term use at full dosage as may cause ulcers and other gastrointestinal problems such as colitis, and you may want to consider giving bute with an antacid therapy, such as gastrogard, to prevent stomach ulcers.
for phenylbutazone as stated in handbook:
Do not administer more than one permitted NSAID at a time. NSAID Disclosure forms are no longer accepted.
Whenever two NSAIDs are administered, one must be discontinued at least three (3) days prior to competing.
The maximum treatment time for phenylbutazone is five days.
Whenever phenylbutazone is administered, the dose should be accurately calculated according to the actual weight of the animal. Each 24 hours, not more than 2.0 milligrams per pound of body weight should be administered, preferably less. For a 1000 pound animal, the maximum daily dose is 2.0 grams, which equals two 1.0 gram tablets, or two 1.0 gram units of paste, or 10.0 cc of the injectable (200 milligrams per milliliter). Neither a total daily dose nor part of an injectable dose should be administered during the 12 hours prior to competing. In the event the phenylbutazone is administered orally, half of the maximum daily dose (1.0 grams per 1000 lbs.) can be administered each 12 hours during a five day treatment program. Phenylbutazone should not be administered for more than five successive days.