Gastrogard (Omeprazole), 2.28gm per tube paste, box of 7

$227.43

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Gastrogard Summary:

 GASTROGARD® (omeprazole) is for treatment and prevention of recurrence of gastric ulcers in horses and foals 4 weeks of age and older.  The active Ingredient in Gastrogard Paste for horses is 37% w/w omeprazole with each syringe containsing 2.28 g of omeprazole.

Action: Omeprazole is a gastric acid pump inhibitor that regulates the final step in hydrogen ion production and blocks gastric acid secretion regardless of the stimulus. Omeprazole irreversibly binds to the gastric parietal cell’s H+, K+ ATPase enzyme which pumps hydrogen ions into the lumen of the stomach in exchange for potassium ions. Since omeprazole accumulates in the cell cannaliculi and is irreversibly bound to the effect site, the plasma concentration at steady state is not directly related to the amount that is bound to the enzyme. The relationship between omeprazole action and plasma concentration is a function of the rate- limiting process of H+, K+ ATPase activity/turnover. Once all of the enzyme becomes bound, acid secretion resumes only after new H+, K+ ATPase is synthesized in the parietal cell (i.e., the rate of new enzyme synthesis exceeds the rate of inhibition).

Dosage and Administration:

Dosage Regimen: For treatment of gastric ulcers, GASTROGARD® Paste should be administered orally once-a-day for 4 weeks at the recommended dosage of 1.8 mg omeprazole/lb body weight (4 mg/kg). For the prevention of recurrence of ulcers, continue treatment for at least an additional 4 weeks by administering GASTROGARD® Paste at the recommended daily maintenance dose of 0.9 mg/lb (2 mg/kg).

Directions for Use: GASTROGARD® Paste for horses is recommended for use in horses and foals 4 weeks of age and older. The contents of one syringe will dose a 1250 lb (568 kg) horse at the rate of 1.8 mg omeprazole/lb body weight (4 mg/kg). For treatment of gastric ulcers, each weight marking on the syringe plunger will deliver sufficient omeprazole to treat 250 lb (114 kg) body weight. For prevention of recurrence of gastric ulcers, each weight marking will deliver sufficient omeprazole to dose 500 lb (227 kg) body weight.

 To deliver GASTROGARD® Paste at the treatment dose rate of 1.8 mg omeprazole/lb body weight (4 mg/kg), set the syringe plunger to the appropriate weight marking according to the horse’s weight in pounds.

To deliver GASTROGARD® Paste at the dose rate of 0.9 mg/lb (2 mg/kg) to prevent recurrence of ulcers, set the syringe plunger to the weight marking corresponding to half of the horse’s weight in pounds.

To set the syringe plunger, unlock the knurled ring by rotating it 1⁄4 turn. Slide the knurled ring along the plunger shaft so that the side nearest the barrel is at the appropriate notch. Rotate the plunger ring 1⁄4 turn to lock it in place and ensure it is locked. Make sure the horse’s mouth contains no feed. Remove the cover from the tip of the syringe, and insert the syringe into the horse’s mouth at the interdental space. Depress the plunger until stopped by the knurled ring. The dose should be deposited on the back of the tongue or deep into the cheek pouch. Care should be taken to ensure that the horse consumes the complete dose. Treated animals should be observed briefly after administration to ensure that part of the dose is not lost or rejected. If any of the dose is lost, redosing is recommended.

If, after dosing, the syringe is not completely empty, it may be reused on following days until emptied. Replace the cap after each use.

Precaution(s): Store below 86°F (30°C). Transient exposure to temperatures up to 104°F (40°C) is permitted.

Caution(s): Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

The safety of GASTROGARD® Paste has not been determined in pregnant or lactating mares.

Do not use in horses intended for human consumption. Keep this and all drugs out of the reach of children. In case of ingestion, contact a physician. Physicians may contact a poison control center for advice concerning accidental ingestion.

Adverse Reactions: In efficacy trials, when the drug was administered at 1.8 mg omeprazole/lb (4 mg/kg) body weight daily for 28 days and 0.9 mg omeprazole/lb (2 mg/kg) body weight daily for 30 additional days, no adverse reactions were observed.

USEF Rules:  No USEF Prohibitions

Description

Gastrogard Summary:

 GASTROGARD® (omeprazole) is for treatment and prevention of recurrence of gastric ulcers in horses and foals 4 weeks of age and older.  The active Ingredient in Gastrogard Paste for horses is 37% w/w omeprazole with each syringe containsing 2.28 g of omeprazole.

Action: Omeprazole is a gastric acid pump inhibitor that regulates the final step in hydrogen ion production and blocks gastric acid secretion regardless of the stimulus. Omeprazole irreversibly binds to the gastric parietal cell’s H+, K+ ATPase enzyme which pumps hydrogen ions into the lumen of the stomach in exchange for potassium ions. Since omeprazole accumulates in the cell cannaliculi and is irreversibly bound to the effect site, the plasma concentration at steady state is not directly related to the amount that is bound to the enzyme. The relationship between omeprazole action and plasma concentration is a function of the rate- limiting process of H+, K+ ATPase activity/turnover. Once all of the enzyme becomes bound, acid secretion resumes only after new H+, K+ ATPase is synthesized in the parietal cell (i.e., the rate of new enzyme synthesis exceeds the rate of inhibition).

Dosage and Administration:

Dosage Regimen: For treatment of gastric ulcers, GASTROGARD® Paste should be administered orally once-a-day for 4 weeks at the recommended dosage of 1.8 mg omeprazole/lb body weight (4 mg/kg). For the prevention of recurrence of ulcers, continue treatment for at least an additional 4 weeks by administering GASTROGARD® Paste at the recommended daily maintenance dose of 0.9 mg/lb (2 mg/kg).

Directions for Use: GASTROGARD® Paste for horses is recommended for use in horses and foals 4 weeks of age and older. The contents of one syringe will dose a 1250 lb (568 kg) horse at the rate of 1.8 mg omeprazole/lb body weight (4 mg/kg). For treatment of gastric ulcers, each weight marking on the syringe plunger will deliver sufficient omeprazole to treat 250 lb (114 kg) body weight. For prevention of recurrence of gastric ulcers, each weight marking will deliver sufficient omeprazole to dose 500 lb (227 kg) body weight.

 To deliver GASTROGARD® Paste at the treatment dose rate of 1.8 mg omeprazole/lb body weight (4 mg/kg), set the syringe plunger to the appropriate weight marking according to the horse’s weight in pounds.

To deliver GASTROGARD® Paste at the dose rate of 0.9 mg/lb (2 mg/kg) to prevent recurrence of ulcers, set the syringe plunger to the weight marking corresponding to half of the horse’s weight in pounds.

To set the syringe plunger, unlock the knurled ring by rotating it 1⁄4 turn. Slide the knurled ring along the plunger shaft so that the side nearest the barrel is at the appropriate notch. Rotate the plunger ring 1⁄4 turn to lock it in place and ensure it is locked. Make sure the horse’s mouth contains no feed. Remove the cover from the tip of the syringe, and insert the syringe into the horse’s mouth at the interdental space. Depress the plunger until stopped by the knurled ring. The dose should be deposited on the back of the tongue or deep into the cheek pouch. Care should be taken to ensure that the horse consumes the complete dose. Treated animals should be observed briefly after administration to ensure that part of the dose is not lost or rejected. If any of the dose is lost, redosing is recommended.

If, after dosing, the syringe is not completely empty, it may be reused on following days until emptied. Replace the cap after each use.

Precaution(s): Store below 86°F (30°C). Transient exposure to temperatures up to 104°F (40°C) is permitted.

Caution(s): Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

The safety of GASTROGARD® Paste has not been determined in pregnant or lactating mares.

Do not use in horses intended for human consumption. Keep this and all drugs out of the reach of children. In case of ingestion, contact a physician. Physicians may contact a poison control center for advice concerning accidental ingestion.

Adverse Reactions: In efficacy trials, when the drug was administered at 1.8 mg omeprazole/lb (4 mg/kg) body weight daily for 28 days and 0.9 mg omeprazole/lb (2 mg/kg) body weight daily for 30 additional days, no adverse reactions were observed.

USEF Rules:  No USEF Prohibitions

Additional information

Weight 0.55 lbs
Dimensions 15 x 5 x 5 in

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